Transport of levovirin prodrugs in the h
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Fujun Li; Lei Hong; Cheng-I Mau; Rebecca Chan; Than Hendricks; Chuck Dvorak; Cal
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Article
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2006
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John Wiley and Sons
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English
β 142 KB
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The transport of 10 amino acid ester prodrugs of levovirin (LVV) was investigated in the human intestinal Caco-2 cell line in order to overcome the poor oral bioavailability of LVV, an investigational drug for the treatment of hepatitis C infection. The prodrugs were designed to improve the permeabi