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Dipeptide model prodrugs for the intestinal oligopeptide transporter. Affinity for and transport via hPepT1 in the human intestinal Caco-2 cell line

✍ Scribed by Carsten Uhd Nielsen; Rikke Andersen; Birger Brodin; Sven Frokjaer; Mitchell E Taub; Bente Steffansen


Book ID
114161368
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
121 KB
Volume
76
Category
Article
ISSN
0168-3659

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The transport of 10 amino acid ester prodrugs of levovirin (LVV) was investigated in the human intestinal Caco-2 cell line in order to overcome the poor oral bioavailability of LVV, an investigational drug for the treatment of hepatitis C infection. The prodrugs were designed to improve the permeabi