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Uptake of the cephalosporin, cephalexin, by a dipeptide transport carrier in the human intestinal cell line, Caco-2

โœ Scribed by Anne H. Dantzig; Linda Bergin


Book ID
115729489
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
614 KB
Volume
1027
Category
Article
ISSN
0005-2736

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The transport of 10 amino acid ester prodrugs of levovirin (LVV) was investigated in the human intestinal Caco-2 cell line in order to overcome the poor oral bioavailability of LVV, an investigational drug for the treatment of hepatitis C infection. The prodrugs were designed to improve the permeabi