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Diisobutyl phthalate has comparable anti-androgenic effects to di-n-butyl phthalate in fetal rat testis

✍ Scribed by Julie Borch; Marta Axelstad; Anne Marie Vinggaard; Majken Dalgaard


Book ID
119378271
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
512 KB
Volume
163
Category
Article
ISSN
0378-4274

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## Abstract Adult male rats gestationally exposed to di(n‐butyl)phthalate (DBP) have dysgenetic testes characterized by seminiferous epithelial degeneration, clustering of Leydig cells, and decreased spermatogenesis. Cell proliferation and apoptosis are key processes regulating development of the t