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Fetal testosterone insufficiency and abnormal proliferation of Leydig cells and gonocytes in rats exposed to di(n-butyl) phthalate

✍ Scribed by Eve Mylchreest; Madhabananda Sar; Duncan G. Wallace; Paul M.D. Foster


Book ID
114273808
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
778 KB
Volume
16
Category
Article
ISSN
0890-6238

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## Abstract Adult male rats gestationally exposed to di(n‐butyl)phthalate (DBP) have dysgenetic testes characterized by seminiferous epithelial degeneration, clustering of Leydig cells, and decreased spermatogenesis. Cell proliferation and apoptosis are key processes regulating development of the t