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Dihydropyrancarboxamides Related to Zanamivir: A New Series of Inhibitors of Influenza Virus Sialidases. 2. Crystallographic and Molecular Modeling Study of Complexes of 4-Amino-4H-pyran-6-carboxamides and Sialidase from Influenza Virus Types A and B

✍ Scribed by Taylor, Neil R.; Cleasby, Anne; Singh, Onkar; Skarzynski, Tadeusz; Wonacott, Alan J.; Smith, Paul W.; Sollis, Steven L.; Howes, Peter D.; Cherry, Peter C.; Bethell, Richard


Book ID
111886579
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
194 KB
Volume
41
Category
Article
ISSN
0022-2623

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πŸ“œ SIMILAR VOLUMES


Novel inhibitors of influenza sialidase
✍ Steven L. Sollis; Paul W. Smith; Peter D. Howes; Peter C. Cherry; Richard C. Bet πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 English βš– 221 KB

N-Propylcarboxamides la,b-3a,b have been synthesised from 2,3-didehydro-2,4-dideoxy-4amino-N-acetylneuraminic acid 4. The tertiary amides 2a,b-3a,b are highly potent but selective inhibitors of influenza A sialidase. The exceptional inhibitory activity of the dipropylamides 3a and 3b against influen

Novel inhibitors of influenza sialidases
✍ Paul W. Smith; Steven L. Sollis; Peter D. Howes; Peter C. Cherry; Kevin N. Coble πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 English βš– 289 KB

The structure-activity relationships of a series of 4-amino and guanidino-4H-pyran-2carboxylic acid 6-carboxamides are described. These compounds represent a new class of inhibitor of influenza sialidases and are particularly active against influenza A sialidase. The binding of the Nphenethyl-N-prop