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Dihydrodiols of dibenz(a,c)anthracene

✍ Scribed by Subodh Kumar; Panna L. Kole

Publisher: Elsevier Science
Year: 1987
Tongue: French
Weight: 297 KB
Volume: 28
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)96510-9

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✦ Synopsis

An unequivocal synthesis of dihydrodiols of the mutagenic polycyclic aromatic hydrocarbon, dibenz(a,c)anthracene is described An important aspect of polynuclear aromatic hydrocarbon (PAH)-induced carcinogenesis concerns the mechanism by which these relatively inert molecules are metabolically activated to highly reactive intermediates (ultimate mutagens and carcinogens). The present report is concerned with the PAH, dibenz(a,c)anthracene DBA 1. Although the carcinogenic activity of DBA is disputed' , it has been shown to possess tumor initiating activity similar to that of benz(a)anthracene and chrysene 293 , and displays mutagenic activity higher than that of carcinogenic 495 dibenz(a,h)anthracene . Like other PAHs, DBA binds covalently to nucleic acid in mouse skin6 7.

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