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Diffusion–collision model for protein folding

✍ Scribed by Martin Karplus; David L. Weaver

Publisher
Wiley (John Wiley & Sons)
Year
1979
Tongue
English
Weight
823 KB
Volume
18
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

The basic equations for the elementary step in the diffusion–collision–coalescence model of protein folding are derived for the case of two radially diffusing spherical microdomains. Refinements and biological implications of the mechanism are considered; included are detailed discussions of the parameters of the model, the possibilities of rotational diffusion and surface diffusion in one or two dimensions, the nature of the microdomains, and the application of the model to protein unfolding.

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