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Diffusion–collision model algorithms for protein folding kinetics

✍ Scribed by Zlatko Vasilkoski; David L. Weaver

Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
114 KB
Volume
25
Category
Article
ISSN
0192-8651

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✦ Synopsis

Abstract

The diffusion–collision model (DCM) of protein folding is described qualitatively and quantitatively. The input parameters required to perform a calculation are explained, and the output data are outlined. Three examples are given of calculating DCM folding kinetics: the Engrailed Homeodomain (a three‐helix bundle with three helical microdomains, pdb code 1ENH), protein G (with three microdomains having a β‐hairpin‐α‐helix‐β‐hairpin motif, pdb code 1PGA), and apomyoglobin (with eight helices and seven strong microdomain–microdomain pairings). © 2004 Wiley Periodicals, Inc. J Comput Chem 25: 1101–1107, 2004

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