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Differentiation of T cell precursors in nude mice. Rejection of heart grafts of thymus donor strain

โœ Scribed by R. Seger; K. Rogers; D. Catty


Publisher
John Wiley and Sons
Year
1974
Tongue
English
Weight
329 KB
Volume
4
Category
Article
ISSN
0014-2980

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โœฆ Synopsis


Abstract

Thymus grafted nude mice showed no tolerance to neonatal heart grafts of thymus donor origin. This finding is in contradiction with the Jerne hypothesis on the somatic generation of immune recognition and in agreement with Bretscher's hypothesis on generalized autoimmunity.


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## Abstract BALB/cโ€nu nu mice which have been injected with a congenic thymus cell suspension are able to reject skin grafts from all other strains tested. Mice injected with allogeneic H๏ฃฟ2 incompatible thymus cells do not reject skin grafts. When allogeneic, H๏ฃฟ2 compatible cells are used, grafts f