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Differentiation of homozygous hemoglobin E from compound heterozygous hemoglobin E-β0-thalassemia by hemoglobin E mutation analysis

✍ Scribed by John P. Johnson; Elliot Vichinsky; Deborah Hurst; Anne Camber; Bertram Lubin; Elalne Louie


Book ID
117162063
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
773 KB
Volume
120
Category
Article
ISSN
1097-6833

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Detection of β-thalassemia and hemoglobi
✍ Pranee Winichagoon; Jiraporn Kownkon; Pathai Yenchitsomanus; Varaporn Thonglairo 📂 Article 📅 1989 🏛 Springer 🌐 English ⚖ 222 KB

Enzymatic DNA amplification and polyacrylamide gel electrophoresis, which demonstrate different sizes of DNA fragments, were used to detect the common mutations causing beta-thalassemia and hemoglobin (Hb) E in Thai people. The 4-bp deletion at codons 41 and 42 can be detected directly by polyacryla