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Differentiation of eosinophilic leukemia EoL-1 cells into eosinophils induced by histone deacetylase inhibitors

✍ Scribed by Kenji Ishihara; Aki Takahashi; Motoko Kaneko; Hiroki Sugeno; Noriyasu Hirasawa; JangJa Hong; OkPyo Zee; Kazuo Ohuchi


Book ID
116718959
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
901 KB
Volume
80
Category
Article
ISSN
0024-3205

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A human eosinophilic leukemia cell line, EoL-1. stopped proliferating at the GI phase, differentiated into eosinophilic granule-containing cells, and died by apoptosis when stimulated with dibutyryl cyclic AMP (dbcAMP). To clarify the effects of dbcAMP, the effects of butyrate and CAMP-increasing re