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Differential recognition of the serologically defined HLA-A2 antigen by allogeneic cytotoxic T cells

✍ Scribed by Jan J. Poel; Jos Pool; Els Goulmy; Jon J. Rood

Publisher
Springer-Verlag
Year
1983
Tongue
English
Weight
536 KB
Volume
17
Category
Article
ISSN
0093-7711

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✦ Synopsis

A comprehensive analysis of human alloimmune cytotoxic T lymphocytes (CTLs) specific for the HLA-A2 antigen identified 11% of HLA-A2 positive cells as outliers. In total, 11 unrelated serologically indistinguishable, but distinguishable by cell-mediated lympholysis (CML) HLA-A2 positive outlier cells were identified. The outlier cells could be subdivided in two subgroups according to reactivity patterns obtained with CTLs directed against the HLA-A2 antigen of outlier cells and their inhibitory capacity in specific competitive inhibition experiments. Thus, the serologically defined HLA-A2 specificity can be divided into at least three subtypes using CTLs specific for the HLA-A2 antigen. Moreover, CTLs specific for an HLA-A2 subtype could be induced when responder cells expressed a different HLA-A2 subtype antigen. On the basis of several family studies, we conclude that the subtype HLA-A2 antigens are inherited in a codominant way.

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