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Differential recognition of the serologically defined HLA-A2 antigen by allogeneic cytotoxic T Cells

✍ Scribed by Satoshi Horai; Jan J. Poel; Els Goulmy

Publisher
Springer-Verlag
Year
1982
Tongue
English
Weight
454 KB
Volume
16
Category
Article
ISSN
0093-7711

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✦ Synopsis

Human alloimmune cytotoxic T cells, sensitized selectively against the HLA-A2 antigen, were tested on a panel of selected target cells. Five HLA-A2 positive outlier cells could be identified. These outlier cells were only weakly lysed by HLA-A2 specific CTLs, although they were serologically indistinguishable from the other HLA-A2 positive, strongly lysed target cells. Furthermore, it was found that the outlier cells were poor cold target inhibitors in contrast to the other HLA-A2 positive target cells, which showed adequate inhibition of specific lysis of HLA-A2 positive target cells. Population studies indicate that the frequency of such HLA-A2 outlier cells may be approximately 10%.

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