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Differential involvement and heterogeneous phosphorylation of tau isoforms in progressive supranuclear palsy

✍ Scribed by G.M. Gibb; R. de Silva; T. Revesz; A.J. Lees; B.H. Anderton; D.P. Hanger


Book ID
116752996
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
560 KB
Volume
121
Category
Article
ISSN
0169-328X

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Two extended haplotypes of the tau gene (H1 and H2) have been described. The frequency of H1 haplotype is increased in progressive supranuclear palsy (PSP). PSP is associated with filamentous tau lesions in neurons and glia, which are reportedly composed exclusively of tau isoforms with four repeats