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Glial localization of four-repeat tau in atypical progressive supranuclear palsy

✍ Scribed by Yumiko Motoi; Masashi Takanashi; Masako Itaya; Kazuhiko Ikeda; Yoshikuni Mizuno; Hideo Mori


Book ID
108957691
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
412 KB
Volume
24
Category
Article
ISSN
0919-6544

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Two extended haplotypes of the tau gene (H1 and H2) have been described. The frequency of H1 haplotype is increased in progressive supranuclear palsy (PSP). PSP is associated with filamentous tau lesions in neurons and glia, which are reportedly composed exclusively of tau isoforms with four repeats

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## Abstract The objective of this study is to better define the pathological characteristics of pathologically proven progressive supranuclear palsy (PSP) presenting with the corticobasal syndrome (CBS). PSP is characterized by early falls, vertical supranuclear ophthalmoplegia, and axial rigidity,