Individual and regional variations of phospho-tau species in progressive supranuclear palsy
✍ Scribed by Berta Puig; María Jesus Rey; Isidre Ferrer
- Book ID
- 106073271
- Publisher
- Springer-Verlag
- Year
- 2005
- Tongue
- English
- Weight
- 358 KB
- Volume
- 110
- Category
- Article
- ISSN
- 0001-6322
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Two extended haplotypes of the tau gene (H1 and H2) have been described. The frequency of H1 haplotype is increased in progressive supranuclear palsy (PSP). PSP is associated with filamentous tau lesions in neurons and glia, which are reportedly composed exclusively of tau isoforms with four repeats
## Abstract The objective of this study is to better define the pathological characteristics of pathologically proven progressive supranuclear palsy (PSP) presenting with the corticobasal syndrome (CBS). PSP is characterized by early falls, vertical supranuclear ophthalmoplegia, and axial rigidity,