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Differential Hydrogen Exchange During Biosynthesis of Cytochalasins B and D

✍ Scribed by Ronald Wyss; Christoph Tamm; John C. Vederas

Publisher
John Wiley and Sons
Year
1980
Tongue
German
Weight
255 KB
Volume
63
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Sodium [2‐^13^C,2‐^2^H~3~]acetate was incorporated into cytochalasin B(1) by Phoma exigua and into cytochalasin D (2) by Zygosporium masonii. The ^13^C‐NMR. and ^2^H‐NMR. of the metabolites showed that most of the deuterium was lost except at carbon atoms which are in polyketide chain‐initiating units.

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