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Differential expression of the cyclin-dependent kinase inhibitor P27 in primary hepatocytes in early-mid G1 and G1/S transitions

✍ Scribed by McIntyre, Maritza; Desdouets, Chantal; Sénamaud-Beaufort, Catherine; Laurent-Winter, Christine; Lamas, Eugenia; Bréchot, Christian


Book ID
110062230
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
633 KB
Volume
18
Category
Article
ISSN
0950-9232

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✍ Alessandro Sgambato; Carlo Ratto; Beatrice Faraglia; Marta Merico; Raffaele Ardi 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 139 KB 👁 2 views

The p27 Kip1 protein is a negative regulator of the cell cycle and a potential tumor suppressor gene. Reduced expression of the p27 Kip1 protein has been reported in several human tumors and has been associated with higher tumor grade and increased mortality in breast, lung, colon, prostate, bladder