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Expression of the cyclin-dependent kinase inhibitor p27kip-1 in benign naevi and correlation with Ki-67 proliferative index

✍ Scribed by Stefanaki, C. ;Antoniou, C. ;Stefanaki, K. ;Stratigos, A. ;Constantinidou, V-V. ;Argyrakos, T. ;Karentzou, O. ;Katsambas, A.

Book ID
108667918
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
290 KB
Volume
152
Category
Article
ISSN
0007-0963

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The p27 Kip1 protein is a negative regulator of the cell cycle and a potential tumor suppressor gene. Reduced expression of the p27 Kip1 protein has been reported in several human tumors and has been associated with higher tumor grade and increased mortality in breast, lung, colon, prostate, bladder