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Differential effects on neutrophil activation of staurosporin and its protein kinase C-selective derivative cgp 41231

✍ Scribed by Karl-Heinz Krause; Christian van Delden; Elzbieta Huggler; Antoinette Monod; Daniel P. Lew


Book ID
113398382
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
349 KB
Volume
227
Category
Article
ISSN
0922-4106

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Analogues of staurosporine were synthesized and their ability to inhibit protein kinases was examined. Staurosporine is a potent but non-selective inhibitor of in vitro protein kinase C (PKC) activity (K5, 6.0 nn). The derivative CGP 41 25 I had reduced PKC activity with an IC,, of 50 nn but showed