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Differential responses of staurosporine on protein kinase C activity and proliferation in two murine neuroblastoma cell lines

✍ Scribed by D.R.K. Mohan; R. Nagarathna; M. Krishna; J.C. Jagtap; Padma Shastry

Book ID
117469388
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
434 KB
Volume
139
Category
Article
ISSN
0304-3835

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Activation of cyclic AMP-dependent prote
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DEAE-cellulose chromatography of the 20,000g supernatant fraction of homogenates of C-1300 murine neuroblastoma (clone N2a) yields one major and two minor peaks of cyclic AMP-dependent protein kinase activity. Assessment of the endogenous activation state of the enzyme(s) reveals that the enzyme is