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Differential inhibition of cytosolic and membrane-derived protein kinase C activity by staurosporine and other kinase inhibitors

✍ Scribed by Joanna Budworth; Andreas Gescher


Book ID
115930620
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
431 KB
Volume
362
Category
Article
ISSN
0014-5793

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Abbractz The synthesis sod b vibu protein kinase C (PKC) inhibition ofa series of staurosporine derivatives is descrii. Essential foractivityisafneNHofIhcLadampwtionofthemolecule.Alargevarictyofarbslitucntsistolcra~atthcsecondaryamine, altlwugh in mcst cases these modifications I& to a dccrrasc in a