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Differential effects of l-buthionine sulfoximine and ethacrynic acid on glutathione levels and mitochondrial function in PC12 cells

✍ Scribed by J. Seyfried; F. Soldner; J.B. Schulz; T. Klockgether; K.A. Kovar; U. Wüllner

Book ID
117477495
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
214 KB
Volume
264
Category
Article
ISSN
0304-3940

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✍ Robert T. Dorr; James D. Liddil; Michelle J. Soble 📂 Article 📅 1986 🏛 Springer US 🌐 English ⚖ 601 KB

The glutathione (GSH) synthesis inhibitor, buthionine sulfoximine (BSO) was tested for cytotoxicity and thiol depletion in murine and human tumor cells in vitro, and for its antitumor activity and toxicity in vivo. The cell lines used in these studies included murine L-1210 leukemia, human RPMI 8226