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Effects of D,L-buthionine-S,R-sulfoximine on cellular thiol levels and the oxygen effect in Chinese hamster V79 cells

✍ Scribed by Myles B. Astor; Eric J. Hall; John E. Biaglow; Beth Hartog

Publisher: Elsevier Science
Year: 1984
Tongue: English
Weight: 416 KB
Volume: 10
Category: Article
ISSN: 0360-3016
DOI: 10.1016/0360-3016(84)90325-0

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## Multidrug -resistance (MDR) is characterized by the presence of a 170 kDa glycoprotein (P-glycoprotein) in the plasma membrane. P-glycoprotein is thought to act as an efflux pump, leading to reduced drug accumulation in MDR cells. This defect in drug accumulation can be overcome by membrane tra