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Differential effects of inactivated Axin1 and activated β-catenin mutations in human hepatocellular carcinomas

✍ Scribed by Zucman-Rossi, J; Benhamouche, S; Godard, C; Boyault, S; Grimber, G; Balabaud, C; Cunha, A S; Bioulac-Sage, P; Perret, C

Book ID: 110071831
Publisher: Nature Publishing Group
Year: 2006
Tongue: English
Weight: 272 KB
Volume: 26
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1209824

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## Abstract β‐Catenin plays a key role in the Wnt signaling pathway, and mutations of __CTNNB1__, the gene that encodes β‐catenin, have been identified in about one‐fourth of human hepatocellular carcinomas from regions of low aflatoxin B1 exposure. In this study 62 hepatocellular carcinomas (HCCs)