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PIN1 overexpression and β-catenin gene mutations are distinct oncogenic events in human hepatocellular carcinoma

✍ Scribed by Pang, Roberta; Yuen, John; Yuen, Man Fung; Lai, Ching Lung; Lee, Terence K W; Man, Kwan; Poon, Ronnie T P; Fan, Sheung Tat; Wong, Chun M; Ng, Irene O L


Book ID
110068568
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
194 KB
Volume
23
Category
Article
ISSN
0950-9232

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## Abstract β‐Catenin plays a key role in the Wnt signaling pathway, and mutations of __CTNNB1__, the gene that encodes β‐catenin, have been identified in about one‐fourth of human hepatocellular carcinomas from regions of low aflatoxin B1 exposure. In this study 62 hepatocellular carcinomas (HCCs)