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Overexpression of orphan G-protein–coupled receptor, Gpr49, in human hepatocellular carcinomas with β-catenin mutations

✍ Scribed by Yoshiya Yamamoto; Michiie Sakamoto; Gen Fujii; Hitomi Tsuiji; Kengo Kenetaka; Masahiro Asaka; Setsuo Hirohashi

Book ID
111722097
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
185 KB
Volume
37
Category
Article
ISSN
0270-9139

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✍ Theodora R. Devereux; Mariana C. Stern; Gordon P. Flake; Mimi C. Yu; Zhen-Quan Z 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 585 KB

## Abstract β‐Catenin plays a key role in the Wnt signaling pathway, and mutations of __CTNNB1__, the gene that encodes β‐catenin, have been identified in about one‐fourth of human hepatocellular carcinomas from regions of low aflatoxin B1 exposure. In this study 62 hepatocellular carcinomas (HCCs)