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Differential effects of disulfiram and diethyldithiocarbamate on small intestinal and liver microsomal benzo[a]pyrene metabolism

✍ Scribed by Roland Grafström; Frank E. Greene

Book ID
115775424
Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
772 KB
Volume
29
Category
Article
ISSN
0006-2952

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## Abstract A rat liver microsome‐mediated bacterial mutagenicity test showed 9‐hydroxybenzo (__a__) pyrene to be significantly more effective as a pre‐mutagen than benzo (__a__) pyrene. Experiments measuring the ability of these compounds to be metabolically activated to moieties that alky late ex