Differential effect of potassium on the action of digoxin and digoxigenin in guinea-pig heart
β Scribed by Tai Akera; Sally A. Wiest; Theodore M. Brody
- Book ID
- 115875824
- Publisher
- Elsevier Science
- Year
- 1979
- Tongue
- English
- Weight
- 684 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0014-2999
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The effect of itraconazole (ITZ) on the pharmacokinetics of digoxin (DGX) was investigated in guinea pigs. The plasma concentrations of DGX in guinea pigs following treatment with ITZ (20 mg/kg intraperitoneally (i.p.)) after intravenous (i.v.) administration of DGX (0.125 mg/kg) were significantly
Ionic strength and ionic specificity were found to have a significant influence on the rectal absorption of gentamicin. Sodium was more effective than potassium in promoting rectal absorption, but the enhancing effect of sodium salicylate could not be totally explained on the basis of ionic strength
Following i.v. injection of digoxin (1Opg kg-') the ratio between digoxin concentrations in the lumen ofjejunal loops perfused in situ and in plasma (L/P) of guinea pigs increased linearily with time. After 3 h, L/P was 8.7, indicating net secretion of digoxin against a concentration gradient. In qu