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Differential characteristics of two new tumorigenic cell lines of human breast carcinoma origin

✍ Scribed by V. J. Möbus; R. Moll; C. D. Gerharz; D. G. Kieback; O. Merk; I. B. Runnebaum; S. Linner; L. Dreher; H.-J. Grill; R. Kreienberg

Publisher
John Wiley and Sons
Year
1998
Tongue
French
Weight
749 KB
Volume
77
Category
Article
ISSN
0020-7136

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✦ Synopsis

Permanent human tumor cell lines are an important tool for the study of breast cancer. Two new breast cancer cell lines (BrCa-MZ-01 and BrCa-MZ-02) were isolated from a solid tumor and a pleural effusion, respectively. One cell line was established from a medullary carcinoma, the other from a ductal carcinoma. These cells exhibit ultrastructural and immunohistochemical features of epithelial cells of mammary origin. Intermediate filament and cytokeratin typing showed a clear predominance of the simple-epithelial cytokeratins CK 8, CK 18 and CK 19, although the expression was reduced in comparison to the hormone receptor-positive reference cell lines MCF-7 and ZR-75-1. Both cell lines produced slow-growing tumors after subcutaneous (s.c.) transplantation of 1 ؋ 10 7 viable tumor cells into nude mice. The cell line BrCa-MZ-01 expresses the estrogen and progesterone receptor, whereas the cell line BrCa-MZ-02 remains negative. Both cell lines are positive for secretion of plateletderived growth factor (PDGF) and transforming growth factor-␤ (TGF-␤), whereas interleukin-6 (IL-6) is only secreted by the cell line BrCa-MZ-02.

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