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Characterization of the differential protein expression associated with thermoresistance in human gastric carcinoma cell lines

✍ Scribed by Pranav Sinha; Julia Poland; Martina Schnölzer; Julio E. Celis; Hermann Lage

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
301 KB
Volume
22
Category
Article
ISSN
0173-0835

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✦ Synopsis

Characterization of the differential protein expression associated with thermoresistance in human gastric carcinoma cell lines

Resistance to chemotherapeutic agents is one of the major problems faced during palliative therapy of tumor cells. Thus, chemotherapy is frequently combined with other modes of therapy such as radiation therapy and/or hyperthermia. Tumor cells respond to heat stress with development of thermotolerance and the interactions between chemo-and thermoresistance phenomena are not clearly understood. In this paper, we analyze the differential protein expression in vitro in human stomach cancer cells, their chemoresistant and thermoresistant counterparts using proteomics. The immediate aim was to identify sets of proteins that may lead to the development of thermoresistance. Based on these results, we aim to develop functional tests and methods for the modulation of thermoresistance and chemoresistance phenomena that may assist the therapy of inoperable cancers.

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