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Differential androgen receptor signals in different cells explain why androgen-deprivation therapy of prostate cancer fails

✍ Scribed by Niu, Y; Chang, T-M; Yeh, S; Ma, W-L; Wang, Y Z; Chang, C

Book ID: 109972330
Publisher: Nature Publishing Group
Year: 2010
Tongue: English
Weight: 810 KB
Volume: 29
Category: Article
ISSN: 0950-9232
DOI: 10.1038/onc.2010.121

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## Background A crucial event in Prostate Cancer progression is the conversion from a hormone-sensitive to a hormone-refractory disease state. Correlating with this transition, androgen receptor (AR) amplification and mutations are often observed in patients failing hormonal ablation therapies. β-C