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Different domains of the glucagon and glucagon-like peptide-1 receptors provide the critical determinants of ligand selectivity

✍ Scribed by S Runge; B S Wulff; K Madsen; H Bräuner-Osborne; L B Knudsen

Book ID
110007671
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
522 KB
Volume
138
Category
Article
ISSN
0007-1188

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## Abstract Glucagon and glucagon‐like peptide‐1 (GLP‐1)are two structurally related hormones that acutely regulate glucose control in opposite directions through homologous receptors. The molecular basis for selectivity between these two hormones and their receptors is of physiological and medicin