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Different clones of t(1;12)/t(12;12) involving the ETV6 gene in a case of acute myeloid leukemia

✍ Scribed by Takashi Saitoh; Takeshi Nakamura; Mituru Inoue; Yoshihiro Hatta; Tetsuo Yamazaki; Jin Takeuchi; Umihiko Sawada; Takashi Horie

Book ID
114135370
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
128 KB
Volume
137
Category
Article
ISSN
0165-4608

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The ETV6 gene is a member of the ETS family of transcription factors and the main target of chromosomal rearrangements affecting chromosome band 12p13. To date, more than 15 fusion partners of ETV6 have been characterized at the molecular level. Most of these fusions encode chimeric proteins with on

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## Abstract The t(7;12)(q36;p13) is a recurrent chromosome abnormality in infant leukemia. In these cases, the involvement of __ETV6__, with disruption of the gene consistently at its 5β€² end, has been reported by several groups. A fusion transcript between __ETV6__ and __HLXB9__ has been detected i