ETV6 is the target of chromosome 12p deletions in t(12;21) childhood acute lymphocytic leukemia
✍ Scribed by Cavé, H; Cacheux, V; Raynaud, S; Brunie, G; Bakkus, M; Cochaux, P; Preudhomme, C; Laï, J L; Vilmer, E; Grandchamp, B
- Book ID
- 110053639
- Publisher
- Nature Publishing Group
- Year
- 1997
- Tongue
- English
- Weight
- 238 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0887-6924
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Seventy-nine acute myeloid leukemias (AML) and myelodysplastic syndromes without cytogenetic evidence of 12p aberrations were investigated by fluorescence in situ hybridization with probes for ETV6 and CDKN1B (previously called TEL and KIP1, respectively) to ascertain whether abnormalities of these
## Abstract The SRC family of kinases is rarely mutated in primary human tumors. We report the identification of a SRC‐like tyrosine kinase gene, __FRK__ (Fyn‐related kinase), fused with __ETV6__ in a patient with acute myelogenous leukemia carrying t(6;12)(q21;p13). Both reciprocal fusion transcri