## Abstract Chromosome rearrangements are found in many acute leukemias. As a result, genes at the breakpoints can be disrupted, forming fusion genes. One of the genes involved in several chromosome aberrations in hematological malignancies is __NUP98__ (11p15). As __NUP98__ is close to the 11p tel
Identification of NIPBL , a new ETV6 partner gene in t(5;12) (p13;p13)-associated acute megakaryoblastic leukemia
✍ Scribed by de Braekeleer, Etienne; Auffret, Régis; García, Juan Ramón González; Padilla, Janet Margarita Soto; Fletes, Carlos Cordova; Morel, Frédéric; Douet-Guilbert, Nathalie; de Braekeleer, Marc
- Book ID
- 118139957
- Publisher
- Informa plc
- Year
- 2012
- Tongue
- English
- Weight
- 150 KB
- Volume
- 54
- Category
- Article
- ISSN
- 1042-8194
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We identified a novel human long fatty acyl CoA synthetase 2 gene, ACS2, as a new ETV6 fusion partner gene in a recurrent t(5;12)(q31;p13) translocation in a patient with refractory anemia with excess blasts (RAEB) with basophilia, a patient with acute myelogenous leukemia (AML) with eosinophilia, a
The ETV6 gene is a member of the ETS family of transcription factors and the main target of chromosomal rearrangements affecting chromosome band 12p13. To date, more than 15 fusion partners of ETV6 have been characterized at the molecular level. Most of these fusions encode chimeric proteins with on