𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Different cation binding to the I domains of α1 and α2 integrins: implication of the binding site structure

✍ Scribed by Tomáš Obšil; Kateřina Hofbauerová; Evžen Amler; Jan Teisinger


Book ID
117111324
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
346 KB
Volume
457
Category
Article
ISSN
0014-5793

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Role of the I-domain in collagen binding
✍ Andreas Kern; Eugene E. Marcantonio 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 172 KB 👁 2 views

Adhesion to collagens by most cell types is mediated by the integrins a1b1 and a2b1. Both integrin a subunits belong to a group which is characterized by the presence of an I domain in the N-terminal half of the molecule, and this domain has been implicated in the ligand recognition. Since purified

Mutagenesis studies of the β I domain me
✍ Joel Raborn; Bing-Hao Luo 📂 Article 📅 2012 🏛 John Wiley and Sons 🌐 English ⚖ 520 KB

## Abstract Three divalent cation binding sites in the integrin β I domain have been shown to regulate ligand binding and adhesion. However, the degree of ligand binding and adhesion varies among integrins. The αLβ2 and α4β7 integrins show an increase in ligand binding affinity and adhesion when on