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Differences in the inducible gene expression and protein production of IL-12p40, IL-12p70 and IL-23: Involvement of p38 and JNK kinase pathways

✍ Scribed by Zlatka Georgieva Dobreva; Spaska Angelova Stanilova; Lyuba Dineva Miteva


Book ID
116398201
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
932 KB
Volume
43
Category
Article
ISSN
1043-4666

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IL-12(p70), a heterodimer composed of two subunits (p35 and p40), is a key cytokine for Th1 mediated inflammatory responses. We dissected the role of IL-12 in the development of 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis by studying mice deficient in IL-12p40, IL-12p35, or IL-12R g 1