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Increased expression of IL-12p70 and IL-23 by multiple dendritic cell and macrophage subsets in plaque psoriasis

✍ Scribed by Yawalkar, Nikhil; Tscharner, Gion G.; Hunger, Robert E.; Hassan, Akmal S.


Book ID
119293453
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
699 KB
Volume
54
Category
Article
ISSN
0923-1811

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The protein kinase C (PKC) family is involved in the regulation of many intracellular signalling pathways. Here, we report that the PKCd isoform regulates IL-12p40/p70 production in macrophages and DC and that PKCd deficiency in mice transforms the 129/Sv healer to a non-healer strain during cutaneo