Differences in the binding of drugs to plasma proteins from newborn and adult man. I
โ Scribed by H. Kurz; A. Mauser-Ganshorn; H. H. Stickel
- Publisher
- Springer
- Year
- 1977
- Tongue
- English
- Weight
- 366 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0031-6970
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๐ SIMILAR VOLUMES
Both in the ilatestinal copper complex and hepatic zinc-thionein of the newborn rat provide immediately available, high-affinity binding sites for Hg 2+. Retention of orally administered Hg 2+ in the gastrointestinal tract is much greater in the 5-day old rat than in the weanling and accounts for mo
The measurement of the unbound drug fraction in plasma is routinely performed at drug concentrations much less than that of plasma proteins. Commonly, the protein has several binding sites of different affinities. The obtained value of the unbound drug fraction does not yield the affinity of each bi