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Differences in active-site gorge dimensions of cholinesterases revealed by binding of inhibitors to human butyrylcholinesterase

✍ Scribed by Ashima Saxena; Ann M.G. Redman; Xuliang Jiang; Oksana Lockridge; B.P. Doctor


Book ID
114009692
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
671 KB
Volume
119-120
Category
Article
ISSN
0009-2797

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It is known that anionic surface residues play a role in the long-range electrostatic attraction between acetylcholinesterase and cationic ligands. In our current investigation, we show that anionic residues also play an important role in the behavior of the ligand within the active site gorge of ac