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Structure–Activity Relationships and Binding Mode in the Human Acetylcholinesterase Active Site of Pseudo-Irreversible Inhibitors Related to Xanthostigmine

✍ Scribed by Stefano Rizzo; Andrea Cavalli; Luisa Ceccarini; Manuela Bartolini; Federica Belluti; Alessandra Bisi; Vincenza Andrisano; Maurizio Recanatini; Angela Rampa

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
679 KB
Volume
4
Category
Article
ISSN
1860-7179

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📜 SIMILAR VOLUMES

Rapid binding of a cationic active site
Rapid binding of a cationic active site inhibitor to wild type and mutant mouse acetylcholinesterase: Brownian dynamics simulation including diffusion in the active site gorge
✍ Sylvia Tara; Adrian H. Elcock; Paul D. Kirchhoff; James M. Briggs; Zoran Radic; 📂 Article 📅 1998 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 133 KB 👁 2 views

It is known that anionic surface residues play a role in the long-range electrostatic attraction between acetylcholinesterase and cationic ligands. In our current investigation, we show that anionic residues also play an important role in the behavior of the ligand within the active site gorge of ac