Differences between familial and sporadic Parkinson’s disease
✍ Scribed by Deepti Vibha; Sachin Sureshbabu; Garima Shukla; Vinay Goyal; Achal Kumar Srivastava; Sumit Singh; Madhuri Behari
- Book ID
- 116820787
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 96 KB
- Volume
- 16
- Category
- Article
- ISSN
- 1353-8020
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## Abstract Tyrosine hydroxylase (TH) is a theoretical candidate gene determining susceptibility to Parkinson's disease (PD), and an association between one allele of a polymorphism at the TH locus and sporadic PD has been reported. We investigated TH polymorphism in 44 patients with sporadic PD, 4
## Abstract Mutations in parkin are the second most common known cause of Parkinson's disease (PD). Parkin is an ubiquitin E3 ligase that monoubiquitinates and polyubiquitinates proteins to regulate a variety of cellular processes. Loss of parkin's E3 ligase activity is thought to play a pathogenic