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Die sterische Einheitlichkeit des synthetischen Val5-Hypertensin II-Asp1-β-amids

✍ Scribed by B. Riniker; R. Schwyzer

Publisher
John Wiley and Sons
Year
1961
Tongue
German
Weight
678 KB
Volume
44
Category
Article
ISSN
0018-019X

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✦ Synopsis

The enzymatic degradation of synthetic Val^5^‐Hypertensin II‐Asp^1^‐β‐amide with trypsin, chymotrypsin, pepsin, subtilisin, carboxypeptidase and leucineaminopeptidase is described, proving the optical purity of all amino‐acid residues (L‐configuration) except His^6^. The configuration of this amino‐acid has been confirmed by its quantitative destruction with L‐amino‐acid oxidase in hydrolysates.

📜 SIMILAR VOLUMES

Synthetische Analoge des Hypertensins. I
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✍ B. Riniker; R. Schwyzer 📂 Article 📅 1961 🏛 John Wiley and Sons 🌐 German ⚖ 487 KB 👁 1 views

The syntheses of the chain‐homologues of hypertensin, H · Arg‐Val‐Tyr‐Val‐His‐Pro‐Phe · OH, H · Asp(NH~2~)‐Arg‐Val‐Tyr‐Val‐His‐Pro · OH, and H · Asp(R)‐Arg‐Val‐Tyr‐Tyr‐Val‐His‐Pro‐Phe · OH (R  −OH and −NH~2~), are described in detail. A system for the nomenclature of such analogues is proposed. The

Synthetische Analoge des Hypertensins II
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✍ B. Riniker; R. Schwyzer 📂 Article 📅 1961 🏛 John Wiley and Sons 🌐 German ⚖ 200 KB 👁 1 views

The syntheses of H · Asp(NH~2~)‐Arg(NO~2~)‐Val‐Tyr‐Val‐His‐Pro‐Phe·OH (I) and of H · Asp(NH~2~)‐Arg‐Val‐Tyr‐Val‐His‐Pro‐Phe · NH~2~ (II), functional derivatives of hypertensin II (angiotensin II), are described. On total acid hydrolysis, nitroarginine and peptides thereof are degraded to arginine an

Synthese hochwirksamer Oktapeptide mit d
Synthese hochwirksamer Oktapeptide mit der vermutlichen Aminosäuresequenz des noch unbekannten Hypertensins II aus Rinderserum (Val5-Hypertensin II und Val5-Hypertensin II-Asp-β-amid)
✍ R. Schwyzer; B. Iselin; H. Kappeler; B. Riniker; W. Rittel; H. Zuber 📂 Article 📅 1958 🏛 John Wiley and Sons 🌐 German ⚖ 515 KB

## Abstract The synthesis of two octapeptides, H · Asp(β‐NH~2~)‐Arg‐Val‐Tyr‐Val‐His‐Pro‐Phe · OH and H · Asp(β‐OH)‐Arg‐Val‐Tyr‐Val‐His‐Pro‐Phe · OH, is described in detail (preliminary communications see footnote 3). The products show a very strong hypertensive activity, and may be identical with t