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Synthese hochwirksamer Oktapeptide mit der vermutlichen Aminosäuresequenz des noch unbekannten Hypertensins II aus Rinderserum (Val5-Hypertensin II und Val5-Hypertensin II-Asp-β-amid)

✍ Scribed by R. Schwyzer; B. Iselin; H. Kappeler; B. Riniker; W. Rittel; H. Zuber

Publisher
John Wiley and Sons
Year
1958
Tongue
German
Weight
515 KB
Volume
41
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

The synthesis of two octapeptides, H · Asp(β‐NH~2~)‐Arg‐Val‐Tyr‐Val‐His‐Pro‐Phe · OH and H · Asp(β‐OH)‐Arg‐Val‐Tyr‐Val‐His‐Pro‐Phe · OH, is described in detail (preliminary communications see footnote 3). The products show a very strong hypertensive activity, and may be identical with the hitherto unknown Val^5^‐hypertensin II of ox blood.

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Synthetische Analoge des Hypertensins. I
Synthetische Analoge des Hypertensins. IV. Synthese der kettenhomologen Peptide (des-Asp1)-Val5-Hypertensin II, (des-Phe8)-Val5-Hypertensin II-Asp1-β-amid, (homo-Tyr4′)-Val5-Hypertensin II und (homo-Tyr4′)-Val5-Hypertensin II-Asp1-β-amid
✍ B. Riniker; R. Schwyzer 📂 Article 📅 1961 🏛 John Wiley and Sons 🌐 German ⚖ 487 KB 👁 1 views

The syntheses of the chain‐homologues of hypertensin, H · Arg‐Val‐Tyr‐Val‐His‐Pro‐Phe · OH, H · Asp(NH~2~)‐Arg‐Val‐Tyr‐Val‐His‐Pro · OH, and H · Asp(R)‐Arg‐Val‐Tyr‐Tyr‐Val‐His‐Pro‐Phe · OH (R  −OH and −NH~2~), are described in detail. A system for the nomenclature of such analogues is proposed. The

Synthetische Analoge des Hypertensins II
Synthetische Analoge des Hypertensins II. Arg(NO2)2, Val5-Hypertensin II-Asp1-β-amid und Val5-Hypertensin II-Asp1-β, Phe8-diamid
✍ B. Riniker; R. Schwyzer 📂 Article 📅 1961 🏛 John Wiley and Sons 🌐 German ⚖ 200 KB 👁 1 views

The syntheses of H · Asp(NH~2~)‐Arg(NO~2~)‐Val‐Tyr‐Val‐His‐Pro‐Phe·OH (I) and of H · Asp(NH~2~)‐Arg‐Val‐Tyr‐Val‐His‐Pro‐Phe · NH~2~ (II), functional derivatives of hypertensin II (angiotensin II), are described. On total acid hydrolysis, nitroarginine and peptides thereof are degraded to arginine an

Synthese hochwirksamer Dekapeptide mit d
Synthese hochwirksamer Dekapeptide mit der Aminosäuresequenz des Val5-Hypertensins I (L-Asparagyl-L-arginyl-L-valyl-L-tyrsyl-L-valyl-L-histidyl-L-prolyl-L-phenylalanyl-L-histidyl-L-leucin und L-Asparaginyl-L-arginyl-L-valyl-L-tyrosyl-L-valyl-L-histidyl-L-prolyl-L-phenylalanyl-L-histidyl-L-leucin)
✍ R. Schwyzer; B. Iselin; H. Kappeler; B. Riniker; W. Rittel; H. Zuber 📂 Article 📅 1958 🏛 John Wiley and Sons 🌐 German ⚖ 906 KB

## Abstract The preliminarily published synthesis(^4^) of decapeptides with the amino acid sequence of Val^5^‐hypertensin I has been repeated several times. The products showed a high hypertensive activity, comparable with that of the corresponding octapeptides [Val^5^‐hypertensin II and Val^5^‐hyp