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Synthetische Analoge des Hypertensins II. Arg(NO2)2, Val5-Hypertensin II-Asp1-β-amid und Val5-Hypertensin II-Asp1-β, Phe8-diamid

✍ Scribed by B. Riniker; R. Schwyzer

Publisher
John Wiley and Sons
Year
1961
Tongue
German
Weight
200 KB
Volume
44
Category
Article
ISSN
0018-019X

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✦ Synopsis

The syntheses of H · Asp(NH~2~)‐Arg(NO~2~)‐Val‐Tyr‐Val‐His‐Pro‐Phe·OH (I) and of H · Asp(NH~2~)‐Arg‐Val‐Tyr‐Val‐His‐Pro‐Phe · NH~2~ (II), functional derivatives of hypertensin II (angiotensin II), are described. On total acid hydrolysis, nitroarginine and peptides thereof are degraded to arginine and ornithine; tyrosine is destroyed to a great extent under the conditions of total acid hydrolysis when nitroarginine is present. Nitroarginine displays a characteristic UV. absorption at 271 mμ.

📜 SIMILAR VOLUMES

Synthetische Analoge des Hypertensins. I
Synthetische Analoge des Hypertensins. IV. Synthese der kettenhomologen Peptide (des-Asp1)-Val5-Hypertensin II, (des-Phe8)-Val5-Hypertensin II-Asp1-β-amid, (homo-Tyr4′)-Val5-Hypertensin II und (homo-Tyr4′)-Val5-Hypertensin II-Asp1-β-amid
✍ B. Riniker; R. Schwyzer 📂 Article 📅 1961 🏛 John Wiley and Sons 🌐 German ⚖ 487 KB 👁 1 views

The syntheses of the chain‐homologues of hypertensin, H · Arg‐Val‐Tyr‐Val‐His‐Pro‐Phe · OH, H · Asp(NH~2~)‐Arg‐Val‐Tyr‐Val‐His‐Pro · OH, and H · Asp(R)‐Arg‐Val‐Tyr‐Tyr‐Val‐His‐Pro‐Phe · OH (R  −OH and −NH~2~), are described in detail. A system for the nomenclature of such analogues is proposed. The