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Dibenzo[a,l]pyrene induced DNA adduct formation in lung tissue in vivo

✍ Scribed by Brinda Mahadevan; Andreas Luch; Claudia F. Bravo; Jennifer Atkin; Linda B. Steppan; Cliff Pereira; Nancy I. Kerkvliet; William M. Baird


Book ID
116333505
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
200 KB
Volume
227
Category
Article
ISSN
0304-3835

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Dibenzo [a,l]pyrene (DB[a,l]P), an extremely potent environmental carcinogen, is metabolically activated in mammalian cells and microsomes through the fjord-region dihydrodiol, trans-DB[a,l]P-11,12-diol, to synand anti-DB[a,l]P-11,12-diol-13,14-epoxides (syn-and anti-DB[a,l]PDEs). The role of seven