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Diastereoselective synthesis of α-substituted-γ-butyrolactones of nucleosides via [1,5]-C,H insertion reactions of α-diazomalonates of nucleosides

✍ Scribed by Lim, Jinsoo; Kim, Yong Hae; Choo, Dong-Joon


Book ID
118254465
Publisher
Royal Society of Chemistry
Year
2000
Tongue
English
Weight
64 KB
Volume
7
Category
Article
ISSN
1359-7345

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The rhodium catalysed C-H insertion reactions of o~-(triethylsilyl)diazoacetates have been studied, facilitating the stereoselective synthesis of t~-(triethylsilyl)-y-lactones. An intriguing 'and unprecedented inversion of stereoselectivity is observed upon changing from rhodium (It) carboxylates to