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Rhodium catalysed reactions of silylated diazoacetates: Stereoselective synthesis of α-silylated γ-lactones via CH insertion

✍ Scribed by Stephen P Marsden; Wai-Kit Pang

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
257 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

The rhodium catalysed C-H insertion reactions of o~-(triethylsilyl)diazoacetates have been studied, facilitating the stereoselective synthesis of t~-(triethylsilyl)-y-lactones. An intriguing 'and unprecedented inversion of stereoselectivity is observed upon changing from rhodium (It) carboxylates to rhodium (It) acetamide as catalyst for insertion to acyclic esters.

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