๐”– Bobbio Scriptorium
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Diastereoselective synthesis of the top half of kijanolide

โœ Scribed by William R. Roush; Bradley B. Brown


Book ID
104212342
Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
278 KB
Volume
30
Category
Article
ISSN
0040-4039

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โœฆ Synopsis


A highly ciiasfereoselective synthesis of the top ha/f (4) of kijanolide is described. The key step is fhe exo and diastereoface selective Die/s-Alder reaction of triene 6 and chiral dienophile 6.


๐Ÿ“œ SIMILAR VOLUMES


Synthesis of 28,29-bisnor-(ยฑ)-kijanolide
โœ Kei Takeda; Shin-go Yano; Eiichi Yoshii ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 244 KB

0(26)-Methyl-28,29-bisnor-(+)-kijanolide (23) has been synthesized via aldol reaction of spirotetronate 3 with octahydronaphthalene aldehyde 4 and subsequent macrocyclization of the resulting product. Kijanolide (1) and tetronolide (2), the aglycons of novel macrocyclic antitumor antibiotics kijanim